Exploring the Conformational Space of Bcl-2 Protein Variants: Dynamic Contributions of the Flexible Loop Domain and Transmembrane Region
Members Footcare of the Bcl-2 protein family regulate apoptosis through interactions with several proteins.A critical intrinsically disordered region (IDR) present in some members of the Bcl-2 family is essential for their function.Also, the structural and conformational plasticity of disordered regions is essential for the regulation of the Bcl-2